Fri Jul 22 2022

25 articles - From Friday Jul 15 2022 to Friday Jul 22 2022

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Guidelines

Guidelines, position statements, white papers, technical reviews, consensus statements, etc…


Meta-analysis

meta-analyses and systematic reviews

Arthritis Res Ther

The effect of disease-modifying anti-rheumatic drugs on skeletal muscle mass in rheumatoid arthritis patients: a systematic review with meta-analysis.

There is no evidence of a significant effect of DMARD therapy, either synthetic or biological, on muscle mass. However, this association should be investigated with more studies.

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Original articles

RCT, clinical trials, retrospective studies, etc…

Arthritis Res Ther

Cationic peptide carriers enable long-term delivery of insulin-like growth factor-1 to suppress osteoarthritis-induced matrix degradation.

CPC-mediated depot delivery of IGF-1 protected cartilage by suppressing cytokine-induced catabolism with only a single dose. CPC is a versatile cationic motif that can be used for intra-cartilage delivery of other similar-sized drugs.

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Cryoglobulinemia in systemic lupus erythematosus: a retrospective study of 213 patients.

CG is frequent in SLE, but mostly asymptomatic. CryoVas features involve mostly joints, skin, and general symptoms. CryoVas in SLE appears to be a specific condition, with a low prevalence of neuropathy, membranoproliferative glomerulonephritis, and severe manifestations.

Pubmed   Journal   ReadQx   PMC

Modulation of B cell activation by extracellular vesicles and potential alteration of this pathway in patients with rheumatoid arthritis.

These data together suggest that m/lEVs have a direct modulatory effect in early responses of B cells through B cell receptor that can potentially fail in patients with RA because of the impact of these vesicles over cells of the innate immune system. This phenomenon can potentially contribute to the loss of tolerance and disease activity in patients with RA.

Pubmed   Journal   ReadQx   PMC

Prognostic meaning of right ventricular function and output reserve in patients with systemic sclerosis.

This study demonstrates that assessment of RV function at rest and during exercise may provide crucial information to identify SSc patients who are at a high risk of poor outcome and for the development of PH and/or PVD.

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Selective block of sensory neuronal T-type/Cav3.2 activity mitigates neuropathic pain behavior in a rat model of osteoarthritis pain.

T-type calcium channel 3.2 (Ca 3.2-targeting strategy in mitigating chronic MIA-OA pain behavior. Validation of the therapeutic potential of this strategy in other OA models may be valuable in future study.

Pubmed   Journal   ReadQx   PMC

The potential roles of type I interferon activated neutrophils and neutrophil extracellular traps (NETs) in the pathogenesis of primary Sjögren's syndrome.

Our data suggest the involvement of neutrophils and enhanced NETosis in pSS patients. Further mechanism study in vitro revealed that type I IFN activation in pSS neutrophils led to mitochondrial damage and related ROS production which finally result in the generation of NETs.

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Arthritis Rheumatol

Epigenetic regulation of profibrotic macrophages in systemic sclerosis- associated interstitial lung disease.

Our results shed light on the underlying changes in chromatin structure and transcription factor regulation of profibrotic SPP1 macrophages in SSc-ILD. Similar alterations in SPP1 macrophages may underpin fibrosis in other organs involved in SSc and point to novel targets for the treatment of SSc-ILD, targeting profibrotic macrophages.

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Identification of three different phenotypes in anti-MDA5 antibody-positive dermatomyositis patients: implications for rapidly progressive interstitial lung disease prediction.

Cluster analysis identified 3 distinct clinical patterns and outcomes in our large cohort of anti-MDA5 + DM patients. Classification of these patients into phenotypes with prognostic values may help physicians to improve the efficacy of clinical decisions.

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Synovial inflammatory pathways characterize anti-TNF-responsive rheumatoid arthritis patients.

Collectively, these data suggest that RA patients with robust responses to anti-TNF therapies are characterized at baseline by immune pathway activation, which decreases following anti-TNF treatment. Understanding mechanisms that define patient responsiveness to anti-TNF may assist in development of predictive markers of patient response and earlier treatment options.

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Rheumatology (Oxford)

Activation of circulating monocytes by low-density lipoprotein a risk factor for Osteoarthritis?

The concept of innate immune training has been widely studied and implicated in atherosclerosis pathology, but its involvement in OA remains uncharted territory. Finally, we evaluate the implications of al this for targeted therapy directed to macrophages and metabolic factors.

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Association between psoriatic disease and lifestyle factors and comorbidities: cross-sectional analysis and Mendelian randomisation.

Observational and genetic evidence converge to suggest that BMI and glycaemic control are associated with increased psoriatic disease risk, while psoriatic disease is associated with increased CAD risk. Further research is needed to understand the mechanism of these associations.

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Autologous stem cell transplantation improves cardiopulmonary exercise testing outcomes in systemic sclerosis patients.

AHSCT improves the aerobic capacity of SSc patients probably reflecting combined increments in lungs, skeletal muscle and cardiac function.

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Evidence of subclinical atherosclerosis in Eosinophilic Granulomatosis with Polyangiitis (EGPA).

Ultrasound markers of subclinical atherosclerosis are increased in EGPA patients as compared with controls, independently of traditional cardiovascular risk factors.

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Lupus myocarditis: review of current diagnostic modalities and their application in clinical practice.

Both echocardiography as well as CMR may detect subclinical myocardial dysfunction and/or injury of which the clinical significance remains uncertain. Considering these challenges, a combined decision-making approach by rheumatologist and cardiologist, interpreting diagnostic test results within the clinical context of the patient is essential to ensure an accurate, early diagnosis of LM.

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Macrophages as determinants and regulators of fibrosis in systemic sclerosis.

Subsequently, we link the activation of macrophages and monocytes to the molecular pathology of SSc, and illustrate the interplay between macrophages and fibroblasts. Finally, we present recent/near-future clinical trials and discuss novel targets related to macrophages/monocytes activation in SSc.

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Toll-like receptor triggering in systemic sclerosis: Time to target.

The presence of DAMPs in association with fibrosis has been highlighted. Given their prominent role in disease this review discusses the evidence of their expression and role in disease pathogenesis and discusses possible therapeutic intervention to mitigate fibrosis.

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Reviews&Editorials

Plenty of the editorials are available as full text through the publisher website using the provided link

Arthritis Rheumatol

Artificial Intelligence and Deep Learning for Rheumatologists: A Primer and Review of the Literature.

Given the important role deep learning methods are likely to play in the future of rheumatology, it is imperative that rheumatologists appreciate the methods and assumptions that underlie the deep learning algorithms in widespread use today, their limitations and the landscape of deep learning research that will inform algorithm development and clinical decision support tools of the future. The best applications of deep learning in rheumatology must be informed by the clinical experience of rheumatologists, so that algorithms can be developed to tackle the most relevant clinical problems.

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Letters&Replies

Letters to the editors and authors’ replies

Arthritis Rheumatol

Walking Associates with Improved Symptom and Structure Outcomes for Knee Osteoarthritis.

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Walking for exercise and subsequent changes of clinical outcomes in patients with knee osteoarthritis: Comment on the article by Lo et al.

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Others

all remaining publications eg case reports, images of the month, etc…

Ann Rheum Dis

Sequential rituximab and mepolizumab in eosinophilic granulomatosis with polyangiitis (EGPA): a European multicentre observational study.

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Rheumatology (Oxford)

"What is fuelling the immune response in systemic lupus erythematosus?" Evaluating the key metabolites driving plasmablast differentiation.

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IRF6 mutation in systemic sclerosis-innocent bystander or contributing factor?

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Point-of-care ultrasonography in large vessel involvement by IgG4-related disease: an opportunity for monitoring?

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Successful use of ixekizumab for glucocorticoid-free remission maintenance in giant cell arteritis.

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